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FLASH GENE
Symbol LRP12 contributors: mct - updated : 06-04-2022
HGNC name low density lipoprotein-related protein 12
HGNC id 31708
DNA
TYPE functioning gene
STRUCTURE 100.02 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4321 - 840 - 2019 31332380
7 - 4378 - 859 - 2019 31332380
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a five fold cysteine-rich repeat homolog to the ligand binding repeat of LDLR
  • an hydrophobic stretch
  • a cytoplasmic domain containing several motifs implicated in endocytosis and signal transduction
  • two CUB domains
  • five LDL-receptor class A domains
  • a C terminal domain of 343 residues
  • HOMOLOGY
    Homologene
    FAMILY subfamily of the LDLR superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 2
    basic FUNCTION
  • putative ST7 receptor protein, with potential role in the transformation process of cells
  • may function as an oncogene in oral tumors
  • is involved in brain development
  • LRP12 and lipoprotein homeostasis are potential molecular target structures for the emergence of epilepsy-associated Focal cortical dysplasias (FCDs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component protein constituent of transmembrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OPDM1 , ALS28
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oral squamous cell carcinomas
    tumoral     --low  
    by hypermethylation in B-cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • represent promising epigenetic markers which may be suitable for monitoring of B-cell lymphoma
  • Therapy target
    ANIMAL & CELL MODELS