Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NBAS contributors: mct/npt - updated : 21-08-2015
HGNC name neuroblastoma amplified sequence
HGNC id 15625
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text 5' end of the gene located 30 kb telomeric to DDX1
STRUCTURE 394.42 kb     52 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
52 - 7299 268 2371 - Scott (2003)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
 pancreas    
 thyroid   highly
Lymphoid/Immunelymph node   highly
nervousbraindiencephalon   
Reproductivefemale systembreastmammary gland highly
 male systemtestis   
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text heart, kidney, lung, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal sequence containing a leucine zipper motif
  • three putative transmembrane helices
  • an endoplasmic reticulum signal sequence
  • two peroxisomal targeting signals
  • two clusters of nuclear localization signals
  • one within the N-terminal sequence
  • the other within the common C-terminal sequence half
  • HOMOLOGY
    Homologene
    FAMILY
  • neuroblastoma-amplified protein family
  • CATEGORY RNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • structural constituent of ribosome
  • DHX34 and NBAS act in concert with core nonsense-mediated mRNA decay (NMD) factors to co-regulate a large number of endogenous RNA targets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ILFS2 , SOPH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in neuroblastoma, low stage in MYCN-amplified tumours
    tumoral   amplification    
    MYCN amplicon, coamplified with N-Myc
    tumoral   translocation    
    fused with ELMO1 in translocation, t(2;7)(p24.3;p14.2), in a case of acute myeloid leukemia transformed from myelodysplastic syndrome (Fujita 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS