GADD family (growth arrest and DNA damage-inducible stress-response gene)
sestrin family
CATEGORY
regulatory
, signaling
growth factor
SUBCELLULAR LOCALIZATION
intracellular
intracellular,nucleus
basic FUNCTION
having a role in the regulation of cell growth
required for normal embryonic left-right determination, playing a role in mediating Nodal signaling, and being indispensable gene for vertebrate left-right asymmetry
exhibit oxidoreductase activity and may function as antioxidants (Lee 2010)
important negative feedback regulator of MTOR whose loss results in various MTOR-dependent, age-related pathologie (Lee 2010)
CELLULAR PROCESS
cell life, proliferation/growth
PHYSIOLOGICAL PROCESS
text
negative regulation of cell proliferation ; response to DNA damage
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
TP53 target gene
physically interacts with FOXH1 or a FOXH1-containing complex
SESN1 and SESN2 interact with the NFE2L2 suppressor KEAP1, the autophagy substrate SQSTM1, and the ubiquitin ligase RBX1 and the antioxidant function of SESNs is mediated through activation of NFE2L2 in a manner reliant on SQSTM1-dependent autophagic degradation of KEAP1