SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleolus
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| critical component of the mature centriole of the centrosome where it locates to the distal appendages |
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in the dense fibrillar component of the nucleolus |
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cell cycle-related functions and localization of ODF2/Cenexin in the mother centriole |
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localizes to centrosomes, to photoreceptor primary cilia, and to basal bodies of ciliated cells of the respiratory epithelium and of the kidney |
basic FUNCTION
| involved in sperm tail function and motility |
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critical centrosomal component whose C-terminal extension is required for proper recruitment of PLK1 and other components crucial for normal mitosis |
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major protein of the cytoskeleton of the sperm tail |
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major component of the sperm tail outer dense fibers |
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having also nucleolar function during spermatogenesis and early embryogenesis |
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may be contributing to assorted ciliopathies |
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KCNA10, ODF2, PXN specific expression patterns imply potential functional significance in the inner ear |
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function of ODF2 is diversified in such a way that each variant has a distinct role in the complex cellular and developmental processes |
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is necessary for the formation of the primary cilium |
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in cycling cells, ODF2 transcription is depressed but becomes up-regulated in quiescent cells |
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cenexin modulates microtubule organization and stability to mediate spindle orientation |
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ODF2 plays a central role in centrosome cohesion |