SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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text
| mainly localized to the mitochondria, endosomes, lysosomes, and proteasome |
basic FUNCTION
| without intrinsic or ARF stimulated GTPase activity |
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playing roles in microtubule-dependent processes |
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binds microtubules in a regulated manner to alter specific aspects of cytokinesis |
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having roles at centrosomes and in regulating microtubule-dependent processes |
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localizes to the cilium and is crucial for ciliogenesis and axoneme formation, as well as cargo displacement of lipidated proteins in the cilium |
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ARL3 is a novel manchette-related protein with an important role in spermiogenesis |
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ARL3 and DYNLL1 regulate dissociation of dynactin from dynein |
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role for ARL3 in the migration of photoreceptor nuclei |
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is a key player in prenylated protein trafficking in rod photoreceptor cells |
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roles for ARL2, in concert with its closest paralog ARL3, in the traffic of farnesylated cargos between membranes and specifically to cilia and photoreceptor cells |
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ARL2 and ARL3 play a fundamental role as regulators of trafficking of lipid modified proteins between different compartments |
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RP2 and ARL3 regulate the trafficking of specific kinesins to cilia tips |
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binary functions of ARL3-GTP as a key molecule in late-stage photoreceptor ciliogenesis and cargo displacement factor |
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plays important role in regulating ciliary trafficking, ans is likely necessary for autophagy |
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small GTP-binding protein that is involved in directing lipid-modified proteins into the cilium in a GTP-dependent manner |