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FLASH GENE
Symbol UBE2L6 contributors: mct - updated : 20-02-2012
HGNC name ubiquitin-conjugating enzyme E2L 6
HGNC id 12490
DNA
TYPE functioning gene
STRUCTURE 16.68 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 1283 17 153 - 2000 10894956
4 splicing 1269 10 87 - 2000 10894956
  • containing an alternate 5' exon
  • using a downstream start codon compared to variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   moderately
    Hearing/Equilibriumear   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  moderately
     female systemuterus  moderately
    Respiratorylung   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    cell lineage
    cell lines
    fluid/secretion blood, lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved UBC domain of 150 aa harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • HOMOLOGY
    interspecies homolog to rattus Ube2l6 (73.9pc)
    homolog to murine Ube2l6 (75.7pc)
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
  • UBE2E family of UBCs
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the covalent attachment of ubiquitin to other proteins
  • functioning in the E6/E6-AP-induced ubiquitination of p53/TP53
  • implicated primarily in processes in the nucleus, is a previously unrecognized important modulator of leukemic cell survival
  • ubiquitylates and promotes the degradation of CDKN1A, both during the normal cell cycle and in UV-irradiated cells
  • CELLULAR PROCESS cell cycle
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • second step of ubiquitin conjugation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • identified in a two hybrid screen through specific interaction with E6AP (E3) ubiquitin protein ligase in the E6-dependent ubiquination of TP53
  • both UBE2L3 and UBE2L6 bind to RNF19B
  • targets active FMS-like tyrosine kinase 3 (FLT3) for proteasomal degradation
  • RNF8 regulates K48- and K63-linked poly-ubiquitylation via differential RING-dependent interactions with its E2s UBE2L6 and UBE2N, respectively
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS