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FLASH GENE
Symbol GUCY1B2 contributors: npt - updated : 04-07-2006
HGNC name guanylate cyclase 1, soluble, beta 2
HGNC id 4686
DNA
TYPE functioning gene
STRUCTURE 71.37 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D13S263 - D13S1312 - D13S328 - D13S168 - D13S1836 /GUCY1B2 - D13S155 - D13S176 - qter
Authors Behrends (99)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to C.elegans k08d10.2
ortholog to rattus beta2 subunit
Homologene
FAMILY
  • adenylyl cyclase class-4/guanylyl cyclase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text soluble forms and membrane-associated receptor forms
    basic FUNCTION
  • guanylate cyclase, beta 2 subunit
  • inhibiting the nitric oxide (No) stimulated activity of the alpha 1/beta 1 form of guanylate cyclase
  • maybe involved in the regulation of blood pressure
  • playing a major role in the cardiovascular system as a receptor for nitric oxide
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling
    a component
  • an alpha and beta chains
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
    cell & other
    REGULATION
    activated by nitric oxide in the presence of magnesium or manganese ions
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS