basic FUNCTION
| negative regulator of G protein signaling 11, functioning as GTPase-activating protein for G protein alpha subunits, G alpha i, G alpha o |
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RGS7, RGS11, and their binding partner GNB5 are localized to the dendritic tips of retinal ON bipolar cells (ON-BPC), and act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways |
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RGS7 and RGS11 act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways |
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RGS7 and RGS11 are the key GTPase accelerating proteins (GAPs) in the GRM6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses |
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action of RGS7 and RGS11 is required for the generation of rod ON-BC light responses with high sensitivity and speed |
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GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1 |