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FLASH GENE
Symbol MFNG contributors: mct - updated : 03-07-2019
HGNC name MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
HGNC id 7038
DNA
TYPE functioning gene
STRUCTURE 17.28 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2040 36.2 321 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila manic fringe
homolog to murine Mfng
Homologene
FAMILY
  • fringe gene family
  • glycosyltransferase 31 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • essential mediator of somite segmentation and patterning
  • putative regulator of developmental processes through alternative regulation of the sensitivity of NOTCH receptor genes for their specific ligands (delta, Jagged 2)
  • glycosyl transferase with N-acetylglucosaminyltransferase activity with elongation of 0-linked fucose residues,on side chains located at some of the EGF-repeats of NOTCH*
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    Notch pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in colorectal cancer, MFNG imposes a negative correlation between JAG1 and NOTCH1, being high JAG1 in the absence of MFNG predictive of poor prognosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS