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FLASH GENE
Symbol BYSL contributors: mct/npt - updated : 06-02-2023
HGNC name bystin-like
HGNC id 1157
DNA
TYPE functioning gene
STRUCTURE 24.29 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1718 49.5 437 - 2021 33628587
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systemuteruscervix highly
 female systemplacenta  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text in placenta from the 6th week of pregnancy, found in the cytoplasm of the syncytiotrophoblast in the chorionic villi, and in endometrial decidual cells at the utero placental interface (Suzuki 1999)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • bystin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation
    basic FUNCTION
  • binding directly to trophinin and tastin which mediate the homophilic adhesion between trophoblast and endometrial epithelial cells
  • cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation (Fukuda 2008)
  • may play multiple roles in cells, and have a conserved function to facilitate ribosome biogenesis required for cell growth
  • may promote cell proliferation by facilitating ribosome biogenesis, specifically in the production of the 40S subunit
  • plays a key role during the transition from silent trophectoderm to an active trophoblast upon trophinin-mediated cell adhesion (Fukuda 2008)
  • encode an accessory protein for cell adhesion that participates in early embryo implantation
  • upregulated BYSL expression plays a role in hepatocarcinogenesis
  • BYSL is an important promoter of multiple tumor progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of c-MYC is consistent with a role for bystin in rapid protein synthesis, which is required for actively growing cells (Fukuda 2008)
  • associate with trophinin by presumably forming an active adhesion machinery (Aoki 2000)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancers
    tumoral fusion      
    BYSL-TFEB fusion in sarcomatoid renal cell tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • BYSL seems to be a promising early marker of severe hypoxic-ischemic changes in neuropathological examination of forensic cases
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    candidate target for the treatment of glioma
    cancerbone 
    candidate target for the treatment of chondrosarcoma
    ANIMAL & CELL MODELS