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FLASH GENE
Symbol COX15 contributors: mct - updated : 29-03-2020
HGNC name COX15 homolog, cytochrome c oxidase assembly protein (yeast)
HGNC id 2263
DNA
TYPE functioning gene
STRUCTURE 37.84 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text several diverging in the 3'utr
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3791 - 388 - 2003 12474143
  • COX15 - variant 2
  • 9 - 5030 46 410 - 2003 12474143
    9 - 3428 - 388 - 2003 12474143
    9 - 4947 - 231 - 2003 12474143
    9 - 5003 - 401 - 2003 12474143
    8 - 4121 - 298 - 2003 12474143
    8 - 4875 - 298 - 2003 12474143
    8 - 5020 - 372 - 2003 12474143
    9 - 4276 - 419 - 2003 12474143
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal mitochondrial leader peptide
  • five transmembrane domains
  • HOMOLOGY
    interspecies homolog to yeast Cox15
    Homologene
    FAMILY COX15/ctaA family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus,nucleoplasm
    text inner mitochondrial membrane in yeast
    basic FUNCTION
  • assembly of the backbone of c oxidase
  • playing an essential role in mitochondrial heme modification
  • plays a key role in the terminal component of the mitochondrial respiratory chain
  • increase in cell viability due to COX15 expression is consistent with its role in oxidative phosphorylation as an assembly factor for cytochrome c oxidase and its involvement removing apoptosis-inducing oxygen radicals
  • displays a role in cytochrome c oxidase assembly, which is independent of its functions as the heme a synthase
  • exhibits homotypic interactions, forming highly stable complexes dependent upon hydrophobic interactions
  • COX15 multimerization is important for heme a biosynthesis and/or transfer to maturing cytochrome c oxidase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidase c (ferrocytochrome c : oxygen oxidoreductase) complex,terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the elctron transfer from reduced cytochrome c to molecule oxygen
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FHCM1 , COX15D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in a bilateral ocular persistent fetal vasculaturev
    constitutional     --over  
    COX 15 mRNA was significantly more abundant in the cerebral tissue of Alzheimer Disease patients
    Susceptibility to Alzheimer disease
    Variant & Polymorphism SNP
  • c+1120C>T SNP in COX15 were significantly less represented in the patient with AD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS