basic FUNCTION
| tight junction specific obliteration of the intercellular space |
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creating charge specific channels in the paracellular space |
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Ca2+ independent cell adhesion activity |
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direct downstream target gene of snail family factors in epithelial cells |
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involved in the beta-catenin-Tcf/LEF signaling pathway |
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role in airway tight junctional permeability |
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role in the regulation of cellular transformation, tumor growth, and metastasis |
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a key factor for Hepatitis C virus entry |
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with CLDN9 and CLDN6, are entry cofactors for hepatitis C virus HCV (Meertens 2008) |
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plays an important role in cancer invasion and metastasis (Kondo 2008) |
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involved in regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene with occludin independently of E-cadherin (Harten 2009) |
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necessary and sufficient to induce invasive behavior in liver cells and PRKCD signaling pathway is critically required for CLDN1-induced acquisition of the malignant phenotype (Yoon 2010) |
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essential role for Claudin-CD81 complexes in HCV infection |
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has a causal role in the epithelial-mesenchymal transition (EMT) in human liver cells |