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FLASH GENE
Symbol TULP3 contributors: mct - updated : 18-04-2011
HGNC name tubby like protein 3
HGNC id 12425
DNA
TYPE functioning gene
STRUCTURE 50.27 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D12S1867 - D12S341 - D12S1587 - CACNA1C - TULP3 - D12S1685 - cen
Authors Nishina (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3106 - 442 - 2001 11375483
12 - 2001 - 501 - 2001 11375483
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinethyroid    
Nervousbrainhindbraincerebellum  
 brainbasal nucleicorpus callosum  
 spinal cord    
Reproductivefemale systemuteruscervix highly
 female systemovary  highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
visualeye
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • two nuclear localization signals (NLS), AA 37-40, AA 258-61
  • the first overlapping a motif of glutamines flanked by basic residues, modifying the NLS to a nucleolar localization signal, also containing a stretch of 15 predominantly hydrophobic flanked by charged residues and reminiscent of a membrane anchor domain
  • HOMOLOGY
    interspecies homolog to murine Tulp3
    intraspecies homolog to TUB
    Homologene
    FAMILY tubby-like gene family
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • membrane bound transcription regulator
  • function as membrane-bound transcription regulators that translocate to the nucleus in response to phosphoinositide hydrolysis, providing a direct link between G-protein signaling and the regulation of gene expression
  • potential role as a negative regulatory factor in the Hh pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to the IFT-A complex, linked to retrograde ciliary transport, but, surprisingly, the IFT-A complex has a second role directing ciliary entry of TULP3
  • TULP3-IFT-A interaction suggests how these proteins cooperate during neural tube patterning
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tulp3(-/-) murine embryos show expansion of Shh target gene expression and display a ventralization of neural progenitor cells in the caudal neural tube