basic FUNCTION
| RNA helicase with RNA dependent ATPase activity |
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involved in translation initiation, nuclear and mitochondrial splicing and ribosome and spliceosome assembly |
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important transcriptional regulator, functioning as a coactivator or corepressor, depending on the context of the promoter and the transcriptional complex |
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may act as a tumor cosuppressor in governing p53 transcriptional activity |
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proliferation-associated nuclear antigen, reacting with the simian virus 40 tumor antigen |
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playing a critical role with DDX17 in promoting the assembly of proteins required for formation of the transcription initiation complex and chromatin remodeling |
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coactivator of MYOD1 |
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may be involved in pre-mRNA splicing |
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may also confer apoptosis resistance by upregulation of X-chromosome-linked inhibitor apoptosis protein-associated factor 1 |
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phosphorylated DDX5 protects cells from programmed cell death by preventing procaspase-8 from proteolytic cleavage |
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androgen receptor transcriptional coactivator |
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involved in multiple myeloma tumorigenesis |
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DDX5 and DDX17 have been shown to act as transcriptional co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ESR1) |
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crucial role for DDX17 in ESR1 co-activation and oestrogen-dependent cell growth and likely distinct but important roles for both DDX5 and DDX17 in regulating ESR1 activity in breast cancer |
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repressor of fibrogenic genes in hepatic stellate cells through interaction with transcriptional complexes |
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is a key TP53-independent target of the CDKN2A and is a novel non-oncogene participant in ribosome biogenesis |
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DDX5 and DDX17 have a dual role in the control of the pro-migratory NFAT5 transcription factor |
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DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation |
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RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation |