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FLASH GENE

Symbol

KRT37

contributors: mct/npt - updated : 01/10/2008

HGNC name	keratin 37
HGNC id	6455

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	4.30 kb     7 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

regionally located

clustered with other acidic hair keratins in a region spanning 190kb

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KRT37 7 - 1718 49 449 - Schweizer (2006)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Reproductive male system testis       Skin/Tegument skin appendages hair follicle

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal cysteine-rich domain
	a central rod domain composed of 4 alpha helical coiled-coil repeats separated by linker region
	a C terminal globular region

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY	intermediate filament family
	type I keratin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament

basic FUNCTION

structural constituent of cytoskeleton activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimerizes with type II keratins to form hair and nails

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS