basic FUNCTION
| inducing apoptosis |
|
stimulating the proliferation of T cells and functioning as a costimulatory factor for the activation of lymphoid cells |
|
mediated adhesion of platelets to endothelium significantly, occurring both under static and dynamic flow conditions |
|
platelet-associated and involved in adhesion of platelets to endothelium while soluble form induces a pro-inflammatory state in vascular endothelial cells |
|
may thus be implicated in the pathogenesis of atherosclerosis and acute coronary syndrome, as evidenced by serum levels |
|
role for VEGFA and TNFSF14 in macrophage apoptosis during wound healing, an event critical in the resolution of inflammation |
|
important mediator in intestinal inflammation |
|
might be a critical cytokine involved in the development of autoimmune inflammatory diseases |
|
regulate bone marrow niche, such as mesenchymal stem cells (MSCs) differentiation |
|
may contribute to the pathogenesis of airway fibrosis through enhancement of epithelial–mesenchymal transition (EMT) |
|
is a key cytokine in airway inflammation and fibrosis |
|
is involved in T-cell homeostasis and erosive bone disease associated with rheumatoid arthritis |
|
role of TNFSF14 in multiple myeloma-bone disease development |
|
may be an important mediator of skin inflammation and fibrosis in diseases such as scleroderma or atopic dermatitis |
|
regulates myogenesis by supporting cell survival and maintaining a sufficient pool of cells for fusion |
|
myocyte-derived TNFSF14 is a survival factor necessary for myoblast differentiation and skeletal muscle regeneration |
|
promote myeloid differentiation of hematopoietic stem/progenitor cells (HSC/HPCs) |
|
exerts its pro-inflammatory and pro-lipogenesis roles through activating nuclear factor-kappa B (NF-& |
|
954;B) signaling pathway |
|
inhibits melanogenesis in melanocytes via NFKB1 signaling and could be applied in the treatment of cutaneous pigment disorders |
|
can inhibit adipose precursor differentiation into beige adipocytes |