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FLASH GENE
Symbol TNFRSF10B contributors: mct - updated : 07-01-2011
HGNC name tumor necrosis factor receptor superfamily, member 10b
HGNC id 11905
DNA
TYPE functioning gene
STRUCTURE 49.06 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure two Sp1 binding sites responsible for the basal transcription activity
MAPPING cloned Y linked N status confirmed
Physical map
NPM2 8p21.3 nucleophosmin/nucleoplasmin, 2 FGF17 8p21 fibroblast growth factor 17 EPB49 8p21.1 erythrocyte membrane protein band 4.9 (dematin) RAI16 8p21.2 retinoic acid induced 16 FLJ22494 8p21.3 hypothetical protein FLJ22494 HR 8p22-p21 hairless homolog (mouse) FLJ22246 8p21.3 hypothetical protein FLJ22246 LGI3 8p21.2 leucine-rich repeat LGI family, member 3 SFTPC 8p21.2 surfactant, pulmonary-associated protein C BMP1 8p21.2 bone morphogenetic protein 1 PHYHIP 8p21.2 phytanoyl-CoA hydroxylase interacting protein POLR3D 8q21 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa PIWIL2 8p21.2 piwi-like 2 (Drosophila) SLC39A14 8p21.2 solute carrier family 39 (zinc transporter), member 14 PPP3CC 8p21.2 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) LOC389639 8 LOC389639 SCAM-1 8p21.2 vinexin beta (SH3-containing adaptor molecule-1) PDLIM2 8p21.2 PDZ and LIM domain 2 (mystique) DBC-1 8p22 p30 DBC protein BIN3 8p21.2 bridging integrator 3 FLJ14107 8p21.2 hypothetical protein FLJ14107 EGR3 8p23-p21 early growth response 3 MGC22776 8p21.2 hypothetical protein MGC22776 RHOBTB2 8p21.2 Rho-related BTB domain containing 2 TNFRSF10B 8p21 tumor necrosis factor receptor superfamily, member 10b LOC389640 8 LOC389640 TNFRSF10C 8p21 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain TNFRSF10D 8p21 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain TNFRSF10A 8p21 tumor necrosis factor receptor superfamily, member 10a LOC389641 8 hypothetical gene supported by AK124295 MGC29816 8p21.2 hypothetical protein MGC29816 LOC203069 8p21.2 hypothetical protein LOC203069 LOXL2 8p21.3-p21.2 lysyl oxidase-like 2 LYSAL1 8p22-p21.3 lysosomal apyrase-like 1 MSCP 8p21.2 mitochondrial solute carrier protein PRO1496 8p21.2 hypothetical protein PRO1496 LOC389642 8 LOC389642 NKX3-1 8p21 NK3 transcription factor related, locus 1 (Drosophila) LOC137814 8p21.2 similar to homeobox protein NKX2-6 STC1 8p21-p11.2 stanniocalcin 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 4154 - 440 - 2007 17273769
10 - 4067 - 411 - 2007 17273769
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Digestiveintestinelarge intestinecolon  
 liver    
Reproductivefemale systemovary  highly
 male systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage highly in tumor cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text widely in fetal tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative signal peptide, with two extracellular cysteine-rich pseudorepeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail with an intracellular DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to murine Tnfrsf10b
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • inducing a caspase-dependent apoptotic pathway, FADD dependent
  • acting as dosage-dependent tumor suppressor genes whose monoallelic deletion can impair TRAIL-induced apoptosis in B-cell lymphoma
  • playing a role as a regulator of megakaryocytopoiesis
  • with TNFSF10 and TNFRSF10A, play an important role in inflammation
  • TNFRSF10B- death signaling contributes to palmitate-induced apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • its signaling promotes hepatocyte lipoapoptosis
  • a component
  • death signal mediated by TNF-related apoptosis-inducing ligand (TNFSF10) receptor 2/death receptor 5 (DR5) may be a key regulator of cholestatic liver injury
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • FADD
  • protein
  • binding APO2L
  • receptor of TNFSF10
  • TNK2 is an essential player in the spatial regulation of TNFSR10A, TNFSR10B (PMId: 24085293)
  • cell & other
    REGULATION
    induced by TP53,inducible
    by luteolin (plays a role in luteolin-induced apoptosis)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary glioblastoma multiforme
    tumoral     --low  
    in B-cell non-Hodgkin lymphoma (B-NHL)
    tumoral somatic mutation      
    in head and neck cancer,with a mutation also present in the germ line of an affected patient
    tumoral       gain of function
    in colon cancer
    constitutional     --over  
    in patients with nonalcoholic steatohepatitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliversteatosis
    caspase inhibitors in steatohepatitis or other approaches to reduce TNFRSF10B activation hold promise to ameliorate hepatocyte lipoapoptosis in fatty liver disease
    cancerbrainglioma/neuroblstoma
    target for future TNFSF10 therapy of glioblastoma
    cancer  
    application of TNFSF10 or anti-TNFSFR10B mAb therapies to cancer patients
    cancer  
    TNFRSF10B-stimulated JNK activation and its consequent fluxes into the pro-autophagic signaling pathways contribute to the autophagic cell death in cancer cells
    cancer  
    cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis
    ANIMAL & CELL MODELS