basic FUNCTION
| involved in cleavage beta galactosidase |
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cleaving the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins |
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protease that removes monoubiquitin from FANCD2 and PCNA, was thought to reverse the DNA damage response of these substrates |
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involved in deubiquitination of FANCD2 |
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deubiquitinating enzyme for PCNA after DNA damage bypass, and reduces the accumulation of monoubiquitinated PCNA during normal cell division |
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participates in the maintenance of both total and phosphorylated levels of CHEK1 in response to genotoxic stress |
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USP1 deubiquitinase controls a feedback loop that limits CHEK1 activity to rescue DNA-damaged cells |
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regulates DNA repair and the Fanconi anemia pathway through its association with WDR48, and through its deubiquitination of two critical DNA repair proteins, FANCD2-Ub and PCNA-Ub |
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USP1/WDR48 complex promotes homologous recombination, at least in part by suppressing nonhomologous end-joining |
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plays important roles in cancer-related processes, such as the DNA damage response, and the maintenance of the undifferentiated state of osteosarcoma cells |
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is a key senescence regulator controlling genomic integrity and a promising target for anti-cancer therapy |
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novel function of USP1 in the control of beta-cell survival |
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novel function of the USP1-ULK1 axis as a modulator of the switch between canonical and unconventional autophagy |
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USP1 exhibits DNA-mediated activation at the replication fork, protects the fork, and promotes survival in BRCA1-deficient cells |