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FLASH GENE
Symbol CTNNAL1 contributors: mct/npt/pgu - updated : 02-09-2009
HGNC name catenin (cadherin-associated protein), alpha-like 1
HGNC id 2512
DNA
TYPE functioning gene
STRUCTURE 70.91 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2445 81.7 734 - 2008 18374411
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • potential casein kinase and protein kinase C phosphorylation site
  • tyrosine kinase phosphorylation site
  • HOMOLOGY
    interspecies homolog to Catnal1
    intraspecies homolog to alpha-catenin and vinculin
    Homologene
    FAMILY
  • vinculin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • modulating Rho pathway signaling by providing a scaffold for the Lbc Rho guanine -nucleotide exchange factor
  • may contribute to the wound repair and proliferation of bronchial epithelial cells and may serve to fibronectin mediated cell-extracellular adhesion and its signal transduction
  • is a unique regulator of GPCR signaling and represents a unique expansion of the intricate and continually evolving array of GPCR signaling networks
  • have tumorigenic potential because it regulates the nuclear factor-KB (NFKB) pathway
  • promotes tumor growth by preventing cellular senescence
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the E cadherin multiprotein complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AKAP13 (may modulate Rho pathway signaling by providing a scaffold for the AKAP13 Rho guanine nucleotide exchange factor)
  • DTNA recruits alpha-catulin (CTNNAL1) to the ADRA1D/dystrophin-associated protein complex signalosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in placentas of preeclampsia and HELLP syndrome
    tumoral     --over  
    in oral squamous cell carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    downregulating alpha-catulin may be a promising therapeutic approach for cancer treatment
    ANIMAL & CELL MODELS