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FLASH GENE
Symbol TNP2 contributors: mct - updated : 09-09-2006
HGNC name transition protein 2 (during histone to protamine replacement)
HGNC id 11952
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
text structure 5′ flanking regions contain putative TATA boxes and cAMP-response elements (CREs), but the TATA boxes and CREs exhibit gene-specific sequences, and an overwhelming majority of CREs differ from the consensus sequence
MAPPING cloned Y linked N status confirmed
Map see PRM1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text haploid spermatogenic cells during transition histone-protamine
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Tnp2
Homologene
FAMILY family of transition proteins
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • may be involved in chromatin condensation during spermiogenesis
  • conversion of nucleosomal chromatin to the compact, nonnucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins
  • basic chromosomal proteins that replace the histones during chromatin remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS