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FLASH GENE
Symbol VNN1 contributors: - updated : 05-05-2006
HGNC name vanin 1
HGNC id 12705
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text
  • lies in close proximity to VNN3 and VNN2
  • in the same transcriptional orientation
    • STRUCTURE 32.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text minor transcripts were also detected (Galland)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Digestiveintestinesmall intestine   
     liver    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		putative GPI anchored cell surface molecule,containing a leader peptide and a putative GPI-cleavage motif
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Vnn1
    ortholog to Drosophila Vanin-like
    intraspecies homolog to biotinidase
    Homologene
    FAMILY
  • carbon-nitrogen hydrolase family
  • vanin subfamily
    • CATEGORY adhesion , enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • secreted
  • membrane-associated protein by a GPI-anchor
    • basic FUNCTION
  • involved in lymphocyte migration in cell adhesion and in the colonization of the thymus by hematopoietic precursor cells
  • regulation of Sertoli cells
  • pantetheinase activity playing a role in oxidative-stress response
  • hydrolyzing specifically one of carboamide linkages in D-pantetheinase thus recycling pantothenic acid
  • ectoenzyme
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS