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FLASH GENE
Symbol VPS52 contributors: mct - updated : 29-08-2016
HGNC name vacuolar protein sorting 52 (yeast)
HGNC id 10518
DNA
TYPE functioning gene
SPECIAL FEATURE head to head, opposite orientation
text lying in a head to head orientation with the gene encoding ribosomal protein S18
STRUCTURE 21.69 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Map pter - HLA-DPB2 - COL11A2 - RXRB - SLC39A7 - HSD17B8 - RING1 - VPS52 - RPS18 - C6orf11 - TAPBP - cen
Authors Walter (98)
Text see KE@
regionally located identified in the centromeric part of MHC2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 initiation site 3046 82.2 723 - 2009 NP_072047
19 initiation site 3442 75.1 656 - 2009 NP_072047
lacks an internal segment
20 - 2535 - 534 - 2009 NP_072047
20 - 2727 - 598 - 2009 NP_072047
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a putative coiled-coil region
HOMOLOGY
interspecies homolog to yeast S.cerevisiae suppressor of actin mutations 2 like (Sac2p)
homolog to murine Vps52
homolog to rattus Sacm2l
Homologene
FAMILY
CATEGORY unknown/unspecified , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,endosome
basic FUNCTION
  • docking protein
  • involving in actin and chitin localization
  • orchestrates retrograde transport from endosomes to the TGN by promoting vesicle tethering and assembly of SNARE complexes in consecutive, independent steps
  • involved in the retrograde trafficking of endosomes
  • required in the formation of embryonic structures at a later stage of development, revealing hitherto unknown functions of VPS52 in the development of a multicellular organism
  • acting through GARP, VPS52 participates in a membrane-related process of the microRNA pathway
  • Golgi-associated retrograde protein (GARP) complex, which functions in endosome-to-Golgi retrograde vesicular transport, as a critical player in sphingolipid homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSSC1 is required for efficient recruitment of GARP (composed of ANG2, VPS52, VPS53 and VPS54 subunits) to the TGN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS