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FLASH GENE

Symbol

KIFC3

contributors: mct/npt - updated : 12-05-2020

HGNC name	kinesin family member C3
HGNC id	6326

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	104.84 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D16S408 - D16S3334 - D16S3057 - KIFC3 - D16S3204 - D16S3089 - D16S400 - qter
Authors	Hoang (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001318715 20 - 3485 NP_001305644 77 687 - 2019 31481795 NM_001130100 20 - 3359 NP_001123572 92 826 - 2019 31481795 NM_001318711 20 - 3549 NP_001305640 - 768 - 2019 31481795 NM_001318710 20 - 3505 NP_001305639 - 848 - 2019 31481795 NM_001318713 18 - 3525 NP_001305642 - 684 - 2019 31481795 NM_005550 19 - 3330 NP_005541 92.64 833 - 2019 31481795 NM_001318714 21 - 3904 NP_001305643 77 687 - 2019 31481795 NM_001318712 18 - 2982 NP_001305641 - 724 - 2019 31481795 NM_001130099 19 - 3355 NP_001123571 - 687 - 2019 31481795

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Endocrine thyroid         Reproductive male system testis       Respiratory lung         Urinary kidney         Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining retinal pigment epithelium (RPE)     Epithelial secretory glandular endocrine   Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous optic nerve

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal globular domain
	the motor domain with an ATP and the microtubule binding sites
	a long alpa-helical coiled-coil region (stalk region), involved in dimerization
	a small C-terminal motor domain, potentially involved in interaction with other proteins, vesicles or organelles

mono polymer

dimer

HOMOLOGY

interspecies

homolog to murine Kifc3

Homologene

FAMILY

kinesin-like protein family, microtubule (MT) minus end-directed kinesin superfamily protein

CATEGORY

motor/contractile , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	in polarized epithelial cells, localized on membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells (Noda 2001)
	CAMSAP2 anchors likely KIFC3 at microtubule minus ends and immobilizes microtubule arrays in dendrites

basic FUNCTION	playing a role in intracellular transport and mitosis
	plays a complementary role in Golgi positioning and integration with cytoplasmic dynein (Xu 2002)
	participate in polarized transport in epithelial cells as shown in the apical transport of ANXA13-containing vesicles (Hirokawa 2004)
	functions as a regulatory or structural element of the adhesion protein complex rather than as a cargo motor (Meng 2008)
	KIFC3 may play a regulatory role in minus-end directed peroxisomal transport for example by blocking the motor function of dynein at peroxisomes
	may guide free microtubules to their destination at the bridge and/or may slide and crosslink central bridge microtubules in order to stage the cells for abscission
	KIFC3, a minus-end-directed kinesin-14, provides microtubule-based centrosome cohesion
	is important for organizing dendritic microtubules and to control dendrite development

CELLULAR PROCESS	cell cycle, division, mitosis

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

sensory transduction/vision

a component

RAB3IP, RAB10, and the microtubule minus-end-directed kinesin KIFC3 form a peroxisome-associated complex to control the movement of peroxisomes along microtubules, enabling communication between peroxisomes and ciliary pocket membranes

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	transported to cell junctions in a manner dependent on the PLEKHA7-NEZHA complex (Meng 2008)
	cooperates with NEZHA for the maintenance of the zonula adherens (Meng 2008)
	KIFC3 suppresses the ubiquitination and resultant degradation of CDH1 by recruiting USP47 to adherens junction (AJ), a process that may be involved in maintaining stable cell-cell adhesion in epithelial sheets
	KIFC3 is eventually inactivated by NEK2 to enable KIF11-driven bipolar spindle assembly
	KIFC3 has a dendrite-specific distribution and interacts with microtubule minus-end binding protein CAMSAP2

cell & other

micotubules

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in sporadic amyotrophic lateral sclerosis (SALS), and dependent of age

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS