Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PAPSS2 contributors: npt/mct - updated : 10-10-2016
HGNC name 3'-phosphoadenosine 5'-phosphosulfate synthase 2
HGNC id 8604
DNA
TYPE functioning gene
STRUCTURE 88.10 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure no putative TATA box and CCAAT box but possessed many GC boxes (Venkatachalam 2003)
MAPPING cloned Y linked N status confirmed
Physical map
KIAA0261 10q23.31 KIAA0261 LOC340749 10q23.31 similar to Rpl7a protein OPN4 10q22 opsin 4 (melanopsin) LDB3 10q22.3-q23.2 LIM domain binding 3 BMPR1A 10q22.3-q23.2 bone morphogenetic protein receptor, type IA EMILIN3 10q23.31 elastin microfibril interfacer 3 SNCG 10q26.2-q23.3 synuclein, gamma (breast cancer-specific protein 1) APM2 10q23.31 adipose specific 2 KIAA1975 10q23.31 KIAA1975 protein similar to MRIP2 GLUD1 10q23.3 glutamate dehydrogenase 1 MGC5560 10q23.31 hypothetical protein MGC5560 LOC389991 10 similar to synaptotagmin XV isoform a; chr10 synaptotagmin FAM22A 10q23.31 family with sequence similarity 22, member A LOC387697 10 LOC387697 LOC387698 10 similar to KIAA2020 protein LOC118945 10q23.31 similar to Cathepsin L preproprotein MINPP1 10q23.3 multiple inositol polyphosphate histidine phosphatase, 1 PAPSS2 10q23-q23.2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 FLJ14600 10q23.31 hypothetical protein FLJ14600 MGC35136 10q23.31 hypothetical protein MGC35136 PTEN 10q23.3 phosphatase and tensin homolog (mutated in multiple advanced cancers 1) FLJ11218 10q23.31 hypothetical protein FLJ11218 LOC142910 10q23.31 similar to Triacylglycerol lipase, gastric precursor (Gastric lipase) (GL) LOC389992 10 similar to ribosomal protein L7 LIPF 10q23.33 lipase, gastric LOC118934 10q23.31 similar to hypothetical protein 9930115F20 LOC389993 10 similar to lipase A precursor; Lipase A, lysosomal acid, cholesterol esterase LOC340654 10q23.31 similar to bA304I5.1 (novel lipase) MGC22805 10q23.31-q23.32 hypothetical protein MGC22805 AMSH-LP 10q23.33 associated molecule with the SH3 domain of STAM (AMSH) like protein DKFZp761K1824 10q23.32 hypothetical protein DKFZp761K1824 ACTA2 10q22.3-q23.1 actin, alpha 2, smooth muscle, aorta TNFRSF6 10q24.1 tumor necrosis factor receptor superfamily, member 6 CH25H 10q23 cholesterol 25-hydroxylase LIPA 10q23.2-q23.3 lipase A, lysosomal acid, cholesterol esterase (Wolman disease) IFIT2 10q23.3 interferon-induced protein with tetratricopeptide repeats 2 IFIT4 10q23.3 interferon-induced protein with tetratricopeptide repeats 4 LOC389994 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3874 - 619 - 2002 11931637
also called PAPS synthase 2a or variant 2
12 - 3874 - 614 - 2002 11931637
  • also called PAPS synthase 2b or variant 2
  • contains notably an extra five amino acid sequence GMALP
  • EXPRESSION
    Rna function the most significant levels of mRNA were found in condensing and proliferating chondrocytes
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestivemouthtongue    Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly Homo sapiens
    Connectivecartilage  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, major variant in growth plate cartilage
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to PAPSS1 (77 p100)
    Homologene
    FAMILY
  • sulfate adenyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • PAPSS1 was predominantly nuclear, whereas PAPSS2 localised mainly within the cytoplasm
  • basic FUNCTION
  • catalyzing the activation of sulfate in two steps, synthesis of adenosine 5'-phosphosulfate and phosphorylation of APS to generate 3'-phospho-adenosine 5'-phosphosulfate (PAPS)
  • may have a important role in skeletogenesis during postnatal growth
  • may be having a important role of the gene product for cartilage growth and development
  • might regulate osteoblast alkaline phosphates activity and cell mineralization, probably through Smads signal pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS locomotion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed with PAPSS1
  • enhanced PAPSS2/VCAN sulfation axis is essential for SNAI1-mediated breast cancer cell migration and metastasis
  • cell & other
    REGULATION
    induced by during chondrogenesis
    Other regulated by extracellular signal-regulated protein kinase, protein kinase C, and p38 kinase, signaling molecules known to regulate chondrogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s) SEMD4 , BCYM4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    PAPSS2 deficiency is a monogenic adrenocortical cause of androgen excess
    constitutional       loss of function
    causes androgen excess via impaired DHEA sulfation, and is associated with a phenotype resembling polycystic ovary syndrome
    Susceptibility to osteoarthritis(minor role in japanese)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS