protein
| interacting with NFKB (activation of IKBKB causes insulin resistance) |
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cooperating with CHUK for regulating liver immune homeostasis and bile duct integrity (share a redundant function in mediating canonical NFKB signaling in hepatocytes and protecting the liver from TNF toxicity) |
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interacts with FAF1 in response to proinflammatory stimuli (such as tumor necrosis factor-alpha, interleukin-1beta, and lipopolysaccharide) and suppresses IKK activation |
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PPM1A and PPM1B, are IKBKB phosphatases |
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IKBKB physically associated with NAA10 and phosphorylated it at Ser209) |
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NMRAL1 interacts and colocalizes with IKBKB, and inhibits the phosphorylation of IKBKB |
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IKBKG is essential for IKBKB activation by inflammatory stimuli, and also a specificity factor that directs IKBKB activity toward CHUK |
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IKBKB directly phosphorylated MAP3K8 on three serines, including the critical regulatory site, S400 |
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SLC39A8 is a transcriptional target of NFKB1 and functions to negatively regulate proinflammatory responses through zinc-mediated down-modulation of IKBKB activity |
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CCDC22 participates in NFKB1 activation and its deficiency leads to decreased IKBKB turnover, highlighting an important regulatory component of this pathway |
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SNAP23 is phosphorylated by IKBKB, and phosphorylation of SNAP23 controls platelet secretion |
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VDR physically interacts with IKBKB to block NFKB1 activation |
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CHUK and IKBKB physically interacted with RICTOR |
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PHLPP2 interacts with IKBKB, decreases its phosphorylation and the subsequent NFKB1 activation in cancer cells ( |
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NLK functions as a pivotal negative regulator in TNF-induced activation of NFKB1 via disrupting the interaction of MAP3K7 with IKBKB |
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activation of NFKB1 induced translocation of ASAP1 to cytoplasm from cell membrane and nucleus, which resulted in augmented interaction of ASAP1 and IKBKB |
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IKBKB regulates endothelial thrombomodulin in a KLF2-dependent manner |
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CHUK and IKBKB are RELB interacting partners whose activation by TNF promotes RELB phosphorylation at serine 472 |
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IKBKB is an IRF5 kinase that instigates inflammation |
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IKBKB activates two "master" transcription factors of the innate immune system, IRF5 and NFKB1 |
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KLHL21 is a novel negative regulator of IKBKB |
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KLHL21 negatively regulates TNF-activated NFKB1 signaling via targeting IKBKB |
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IKBKB, an upstream IRF5 activator, is phosphorylated in response to the agonist-induced TLR signaling |
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IRAK4 activity regulates likely MAP3K7 and IKBKB activation, leading to the nuclear translocation of IRF5 and induction of inflammatory cytokines in human monocytes |
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unique innate immune activation cascade in which TBK1-IKBKB formed a positive feedback loop to assure robust cytokine production during CGAS-TMEM173 activation |
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novel role for IKBKB in negatively regulating GADD45A protein stability and the contribution of TP53-dependent IKBKB reduction to mediating cancer cell apoptosis |
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VRK2 interacts with IKBKB, phosphorylating its Ser177 and Ser181 residues and thus activating the TNF/NFKB1 signaling pathway |