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FLASH GENE
Symbol TAGLN2 contributors: mct - updated : 22-08-2013
HGNC name transgelin 2
HGNC id 11554
DNA
TYPE functioning gene
STRUCTURE 7.44 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure
  • methylation of its promoter is an important event in vascular smooth muscle cell calcification (high-phosphate medium reduced DNA methyltransferase activity and prevented methylation of the promoter, which was accompanied by an increase in TAGLN2 expression and less calcification)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1608 - 220 - 2001 11401431
    5 - 1419 - 199 - 2001 11401431
    5 - 1384 - 199 - 2001 11401431
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     liver    
     salivary gland   moderately
    Lymphoid/Immunespleen    
     thymus    
     tonsils   highly
    Reproductivefemale systemuteruscervix moderately
     female systemovary   
     male systemtestis   
     male systemprostate   
    Respiratorylung    
    Skin/Tegumentskin   moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectiveadipose  predominantly
    Lymphoid    
    Muscularsmooth   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CH (calponin-homology) domain
  • a calponin-like repeat
  • conjugated Other
    HOMOLOGY
    interspecies homolog to zebrafish SM22alpha
    homolog to rattus Tagln2 (97 pc)
    homolog to murine Tagln2 (96.5 pc)
    intraspecies homolog to transgelin a early marker of smooth muscle differentiation
    Homologene
    FAMILY
  • calponin family
  • CATEGORY unknown/unspecified , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    basic FUNCTION
  • actin-binding protein shown to be a tumor suppressor
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • maybe actin binding
  • unphosphorylated TAGLN2 in CDK14-suppressed cells elicited strong actin-binding ability, a mechanism that possibly halts the actin cytoskeleton dynamics
  • cell & other
    REGULATION
    Other acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    PTTG1 and TAGLN2 are highly expressed in human pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • cross-section of zebrafish SM22alpha-deficient embryo suggests that SM22alpha may play roles in smooth muscle cell morphology transform