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FLASH GENE
Symbol EIF2S3 contributors: npt/mct - updated : 13-11-2014
HGNC name eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
HGNC id 3267
DNA
TYPE anonymous DNA segment
SPECIAL FEATURE escaping inactivation
text escaping X-inactivation
STRUCTURE 23.86 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3486 51 472 - 2005 16288713
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
Homologene
FAMILY
  • GTP-binding elongation factor family
  • EIF2G subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulates the rate of protein translation, and escapes X-inactivation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • CDC123 is critical for EIF2S1, EIF2S2, EIF2S3 activity, and CDC123 is a specific EIF2 assembly factor indispensable for the onset of protein synthesis
  • importance of EIF5 GDI (GDP-dissociation inhibitor) activity, and EIF2S2 acts in concert with EIF5 to prevent premature release of GDP from EIF2S3 and thereby ensure tight control of protein synthesis initiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MEHMO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS