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FLASH GENE

Symbol

CYP2A13

contributors: - updated : 28-11-2005

HGNC name	cytochrome P450, family 2, subfamily A, polypeptide 13
HGNC id	2608

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	7.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

in a cluster including five CYP2As, three CYP2b, three CYP25 genes or pseudogene

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 9 - 1747 56 494 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         reproductive respiratory tract         Respiratory lung           respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium     Epithelial barrier/lining uroepithelium     Epithelial secretory glandular exocrine   Membrane sensory

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

HemoP

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY	cytochrome P450 subfamily IIA
	multigenic cytochrome P450 superfamily of mixed-function monooxygenases

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	acting as a monoxygenase oxygenerating major tobacco-specific carcinogens
	activating the nicotine-derived procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) into DNA-altering compounds

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport , detoxification

PATHWAY

metabolism

drug

signaling

oxidative metabolism

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH, heme

protein

flavoprotein P450 oxidoreductase (POR)

cell & other

REGULATION

induced by

phenobarbital

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to lung cancer

Variant & Polymorphism other	CYP2A13*7 allele increasing the risk of lung cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS