basic FUNCTION
| involved in signal transduction by regulating the intracellular concentration of cyclic nucleotides |
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modulating beta-adrenergic signaling |
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degrades cGMP in smooth muscle cells so as to maintain the contracted state of contractile organs such as the penis, blood vessels, uterus, and intestines |
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regulates bladder smooth muscle tone, strongly limiting the nitric oxide/cGMP signaling |
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role in cardiomyocyte hypertrophy modulation |
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physiological role in restricting the effects of NOS3/GUCY1A3/PRKG signaling pathway to modulating beta-adrenergic stimulation via modulation of the L-type Ca(2+) current (I(Ca), while limiting effects on cardiac contraction |
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may play an important role in the growth of human malignant melanoma MAA cells |
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catalyzes the specific hydrolysis of cGMP to 5'- GMP |
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primary role of myocyte PDE5A regulation to myocardial pathobiology |
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inhibition of endothelial PDE5A improves endothelial function |
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potential role for PDE5A in erythrocytes |