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FLASH GENE
Symbol NDST2 contributors: npt - updated : 17-08-2007
HGNC name N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
HGNC id 7681
DNA
TYPE functioning gene
STRUCTURE 9.67 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3778 100.9 883 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Ndst2
homolog to Drosophila sfl
homolog to C.elegans hst-1
Homologene
FAMILY
  • sulfotransferase 1 family
  • NDST subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • heparan sulfate-N-deacetylase/N-sulfotransferase 2
  • playing a role in heparan biosynthesis
  • catalysing the N-sulfatation and N-deacetylyation of glucosamine of the glycosaminoglycan in the heparin sulfate
  • playing a role in determining the extend of modification of the polysaccharide chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS