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FLASH GENE
Symbol TAB1 contributors: mct/pgu - updated : 21-11-2015
HGNC name TGF-beta activated kinase 1/MAP3K7 binding protein 1
HGNC id 18157
DNA
TYPE functioning gene
STRUCTURE 37.37 kb     11 Exon(s)
MAPPING cloned Y linked N status confirmed
Map see SYNGR1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3240 - 504 - 2008 18456659
TAB1 alpha
11 splicing 1994 - 462 - 2008 18456659
  • TAB1 beta
  • an alternate exon at the 3', 11th and 12th exons of TAB1 were spliced out, and an extra exon, termed exon beta, downstream of exons 11 and 12 was used as the last exon in TAB1beta, and shorter C-terminus(only 27AA)
  • interacts with MAPK14 but not MAP3K7
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • AA 452/453 and 456/457 of TAB1 are novel sites phosphorylated by MAP3K7 as well as by MAPK14 (complex role of AA 452-457 of TAB1 in controlling MAPK14 activity and subcellular localization)
  • C-terminal 68AAs were sufficient to mediate osmotic stress-induced MAP3K7 activation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • neutrophils express MAP3K7, as well as its associated partners, TAB1, TAB2, in both the cytoplasm and nucleus
  • basic FUNCTION
  • involved in the BMP signaling through binding with API3 (XIAP)
  • activation of MAP3K7/TAK1
  • inhibition of TGF beta signaling
  • 'pseudophosphatase', possibly binding to and regulating accessibility of phosphorylated residues on substrates downstream of MAP3K7 or on the MAP3K7 complex itself
  • promotes potentially nitric oxide-induced MAPK14 autophosphorylation
  • playing a role in the inflammatory response, which is independent of the activation of classical MAP3K7 associated signalling cascades
  • upstream adaptor for the activation of the kinase MAP3K7, which in turn couples to the NF-kappaB pathway
  • required to induce MAP3K7 catalytic activity
  • mediates MAP3K7 activation only in a subset of MAP3K7 pathways that are mediated through spontaneous oligomerization of TAB1-MAP3K7
  • both the MAP3K1 PHD and TAB1 are critical for ES-cell differentiation and tumourigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    TGFB,NF-kappa B, Wnt/beta-catenin signaling pathways
    a component
  • complex with MAP3K7 and MAP3K7IP2
  • one of the regulatory subunits of MAP3K7, a protein kinase that lies at the head of three pro-inflammatory kinase cascades
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activator of MAP3K7 (TAK1) leading to NF
  • activating MAPK14 (p38 alpha MAP kinase)
  • binds MAP3K7 and polyubiquitin chains to promote specific sites of phosphorylation in MAP3K7-MAP3K7IP1, which activates IKK signaling to NF-kappaB
  • KCNJ6/MAP3K7IP1 interaction is crucial for BIRK4-induced MAP3K7 and NF-kappaB activation
  • constitutively associated with MAP3K7 through its C-terminal region
  • relationship between two central regulatory pathways in which MAP3K7-MAP3K7IP1-TAB2 selectively induces calcineurin-NFAT signalling through direct phosphorylation of RCAN1, while calcineurin activation diminishes MAP3K7 signalling by dephosphorylation of MAP3K7 and MAP3K7IP1
  • POSTN is involved in the suppression of cell invasiveness via the TAB1/MAP3K7 signaling pathway
  • regulatory subunit of MAP3K7, which functions upstream in the pathways activated by interleukin IL1, tumor necrosis factor (TNF), toll-like receptors (TLRs) and stressors
  • directly interacted with MAP3K7-binding protein 1 (TAB1) and dephosphorylated TAB1 at Ser(438), leading to TAB1-MAP3K7 complex inactivation in T cells
  • RNF4 interacts with the NR2C2-TAB2-TAB3 complex, but not TAB1
  • cell & other
    REGULATION
    Other modified with OGT on a single site, Ser395 (this modification is induced by IL1 and osmotic stress, known inducers of the MAP3K7 signalling cascade)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS