basic FUNCTION
| playing a role in assembling activin signaling molecule and in regulating signal transduction in neuronal cells |
|
seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins |
|
may play a role in regulating activin-mediated signaling in neuronal cells |
|
enhancing the ability of PTEN to suppress AKT1 activation |
|
involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment |
|
is crucial for the cooperation between the CDH2/catenin and the neuroligin-1 systems, leading to a transsynaptic regulation of presynaptic maturation |
|
plays the critical role of maintaining synaptic strength |
|
is required for the integrity of the kidney filter and podocyte survival |
|
USH1G and MAGI2-mediated endocytosis regulates aspects of ciliogenesis |
|
is critical for kidney barrier function |
|
is essential for proper localization of nephrin and the assembly of the slit diaphragm complex |
|
is a scaffolding protein that links cell adhesion molecules, receptors, and signaling molecules to the cytoskeleton and maintains the architecture of cell junctions |
|
MAGI2 and FYN protect DDN from NEDD4L-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI2 in podocytes results in glomerulosclerosis |
|
may contribute to prostate carcinogenesis |