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FLASH GENE
Symbol DZIP3 contributors: mct - updated : 16-12-2014
HGNC name DAZ interacting protein 3, zinc finger
HGNC id 30938
DNA
TYPE functioning gene
STRUCTURE 105.36 kb     33 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC344593 3q13.12 similar to protein tyrosine phosphatase, non-receptor type 11; protein-tyrosine phosphatase 2C; Noonan syndrome 1 LOC344595 3q13.12 hypothetical LOC344595 LOC391563 3 similar to citrate synthase (51.5 kD) (3L304) NYD-SP17 3q13.12 testes development-related NYD-SP17 BBX 3q13.1 bobby sox homolog (Drosophila) LOC285205 3q13.12 hypothetical protein LOC285205 CD47 3q13.1-q13.2 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) ESRRBL1 3q13.13 estrogen-related receptor beta like 1 HHLA2 3q13.13 HERV-H LTR-associating 2 KIAA1000 3q13.13 HERV-H LTR-associating 2 KIAA1524 3q13.13 KIAA1524 protein DZIP3 3q13.1-q13.2 KIAA1524 protein RETNLB 3q13.1 resistin like beta TRIM 3q13 resistin like beta GUCA1C 3q13.1 guanylate cyclase activator 1C MORC 3q13 microrchidia homolog (mouse) LOC151871 3q13.13 hypothetical protein BC018070 DPPA4 3q13.13 developmental pluripotency associated 4 LOC391564 3 similar to H3 histone, family 3B LOC391565 3 similar to peptidyl-Pro cis trans isomerase LOC389140 3 similar to Nuclear transcription factor Y subunit beta (NF-Y protein chain B) (NF-YB) (CCAAT-binding transcription factor subunit A) (CBF-A) (CAAT-box DNA binding protein subunit B) LOC389141 3 similar to laminin receptor 1 (ribosomal protein SA); P40-3, functional; P40-8, functional; laminin receptor 1 (67kD, ribosomal protein SA) LOC151760 3q13.13 hypothetical LOC151760 PVRL3 3q13 hypothetical LOC151760
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
33 - 5568 138 1208 - 2003 12538761
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemovary  highly
 male systemtestis  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to PR repeat protein O
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • the combined presence of RNA binding and E3 activity in DZIP3 raises the possibility that both are mechanistically linked
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, DZIP3 and MEX3B, as well as with their respective ubiquitination substrates, ATXN1 and SNUPN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS