SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| TNXB and KIF11 proteins were co-localized in the cytoplasm in interphase and mitosis, but TNXB did not localize on mitotic spindle microtubules, on which KIF11 prominently localized in mitosis |
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localizes to spindle microtubules during mitosis |
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KIF11 and TPX2, a spindle microtubule-associated protein that suppresses KIF11 motor activity, are enriched on parallel microtubules near spindle poles |
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KIF11, 21B, 13B with distinct effects on synaptic transmission are expressed in the same hippocampal neuron |
basic FUNCTION
| mitotic spindle assembly |
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microtubule motor activity |
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involved in chromosome positioning, centrosome separation, establishing a bipolar spindle during mitosis |
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plus-end-directed motor involved in separation of centrosomes, and in bipolar spindle formation and maintenance during mitosis |
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having essential and nonredundant functions that are necessary for cell viability and early embryonic development |
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critical for spindle assembly during mitosis and has recently been implicated in tumorigenesis |
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functions as a homotetramer, with two motor domains at each end of a central stalk, and contributes to spindle assembly by cross-linking and pushing apart adjacent interpolar microtubules |
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permits microtubules to selectively invade one side of the growth cone by opposing their entry into the other side |
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critical for proper spindle assembly and represents an attractive anticancer target |
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similar to KIF11, KIF15 can drive centrosome separation during bipolar spindle assembly |
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RARRES1, AGBL2, KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis |
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actin-dependent KIF11-opposing forces slow down separation in G2 phase |
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role of KIF11, PLK1 and the NIMA-family kinases in the control of centrosome separation and normal mitotic progression |
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KIF11, KIF15, and dynein work together to build a bipolar spindle and reveal an important role for antagonistic motors in chromosome segregation |
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pauses at microtubule plus ends and enhances polymerization by stabilizing longitudinal tubulin-tubulin interactions, and these activities underlie the ability KIF11 to slide and stabilize microtubule bundles in cells |
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essential role of PTEN in mitosis through regulation of the mitotic kinesin motor EG5 for proper spindle architecture and chromosome congression (pMID: 27492783) |
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is essential to mitosis and cell cycle progression |
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role for KIF11 not only in ocular development but also in maintaining retinal morphology and function |
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acts as a potential oncogene that regulates the development and progression of breast cancer |
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one of the first steps in mitotic spindle assembly is the dissolution of the centrosome linker followed by centrosome separation driven by KIF11 |
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endogenous KIF11 enhances the self-renewal of breast cancer cells by activating the Wnt/CTNNB1 signaling pathway |
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promotes bipolar spindle formation and chromosome movement, and during interphase, KIF11 mediates diverse trafficking processes in the cytoplasm |