basic FUNCTION
| CEP135 and DCTN2 play an important role in assembly and maintenance of functional microtubule-organizing centers |
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play a scaffolding role during centriole biogenesis and acts as a platform protein for CEP250 at the centriole |
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centriolar protein that also localizes to the spermatid basal body |
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has a role in maintaining the structure and organization of the centrosome and of microtubules |
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essential components of the centrosome in particular for a normal neurogenesis |
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role in centriole biogenesis, and at the centrosome as microtubule-organizing center |
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conserved player in centriole and flagella biogenesis, can bind and stabilize MTs and is required for the early steps of central MT pair formation |
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acts to maintain the structural integrity of basal bodies against the forces of ciliary beating in addition to its separable role in basal body assembly |
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is required for the structural integrity of centrioles in proliferating vertebrate cells, a role that also limits centrosome amplification in S-phase-arrested cells |
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since CEP135 is implicated in primary microcephaly, perturbed centrosome asymmetry could potentially contribute to this rare neurodevelopmental disease |
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CEP135 is required for the recruitment of WRAP73 to centrioles |
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WRAP73 and CEP135 have strongly overlapping functions in ciliogenesis |