protein
| interacting with VDR and SNAI1 in colorectal cancer (loss of VDR and TCF8 and presence of SNAI1 is predictor of poor clinical prognosis) |
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associates with two conserved E-box elements in the PKP3 promoter and partially represses the activity of corresponding PKP3 promoter fragments |
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interact with E-box elements in the proximal promoter region of target genes such as E-cadherin |
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interacting with CDH13 (represses CDH13 expression and thus increases the invasive activity of gallbladder cancer) |
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binds to receptor-regulated SMAD2/3 and synergizes with SMAD-mediated transcriptional activation |
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interacting with LLGL2 (suppresses the expression of cell polarity factors, in particular of LLGL2, which we found reduced in colorectal and breast cancers) |
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interacting with NEUROD2 (induces transcription of neuronal genes and ZEB1, which in turn de-represses neuronal differentiation by down-regulating REST, and suppresses competing myogenic fate) |
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interacts with the SWI/SNF chromatin-remodeling protein BRG1 to regulate E-cadherin independently of CTBP1, its traditional co-repressor |
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SNAI1 controls ZEB1 expression at multiple levels and acts cooperatively with TWIST1 in the ZEB1 gene transcription induction |
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required for NTRK2-induced EMT in epithelial cells |
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interacting with WISP3 (WISP3 decreases ZEB1-mediated EMT and invasion by attenuation of IGF1 receptor signaling in breast cancer) |
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GAB2 inhibits CDH1 expression and enhances the expression of ZEB1, a transcription factor involved in epithelial-to-mesenchymal transition (EMT), and cell migration and invasion through the activation of the PI3K pathway |
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CTNNB1/TCF4 binds directly to the ZEB1 promoter and activates its transcription |
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in colorectal carcinoma cells ZEB1 directly activates LAMC2 expression, although these results do not exclude the possibility of concurrent indirect regulation via MIR200 |
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STAT3 may directly mediate EMT(epithelial-mesenchymal transition) progression and regulate ZEB1 expression in colorectal cancer |
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ETV5 modulated ZEB1 expression and CDH1 repression leading to a complete reorganization of cell-cell and cell-substrate contacts |
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binds to an E-box sequence in the AR gene promoter, and physically interacts with AR in human foreskin cells |
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SLC2A3 is a transcriptional target of ZEB1 |
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VANGL1 induced the expression of the epithelial-mesenchymal transition (EMT) markers (N-cadherin, ZEB1, ZEB2, SNAI1 and SNAI2) as well as the glioma stemness markers (CD133, ALDH1 and EPHB1) |
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OVOL2 acts as a direct transcriptional repressor of the established PPCD3-associated gene ZEB1 |
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PTBP3 is a regulator of EMT that acts by governing expression of ZEB1, and leading to an oncogenic function of PTBP3 |
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GRHL2 is a transcription factor that suppresses epithelial-to-mesenchymal transition (EMT) and is a direct transcriptional repressor of ZEB1 |
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ZEB1 is a transcriptional activator of SOX8 that enhanced SOX8 expression by binding to its promoter |
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ZEB1 represses neural differentiation and cooperates with CTBP2 to dynamically regulate cell migration during neocortex development |
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interaction between ZEB1 and CTBP2 in the embryonic cerebral cortex is required for ZEB1 to elicit its effect on the multipolar-to-bipolar transition, but not its suppression of NEUROD1 |
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ZEB1 positively correlates with HDGF expression, and co-expression of ZEB1 and HDGF promotes the pathogenesis of endometrial carcinoma (EC) |
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cytosolic EPCAM cooperates with HRAS to regulate epithelial to mesenchymal transition through ZEB1 |