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FLASH GENE
Symbol AKAP11 contributors: mct - updated : 19-01-2013
HGNC name a kinase (PRKA) anchor protein 11
HGNC id 369
DNA
TYPE functioning gene
STRUCTURE 51.11 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
Map cen - D13S168 - AKAP11 - CPB2 - D13S153 - qter
Authors GeneMap (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 9926 220 1901 - 2002 12147701
- - 5947 - 1469 - 2002 12147701
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Nervousbrain    
 nerve   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure an amphipathic helix binding domain
HOMOLOGY
interspecies homolog to rattus A kinase anchoring protein AKAP220
Homologene
FAMILY AKAP110 family
CATEGORY chaperone/stress
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,nucleus,nucleoplasm
text cytoplasmic in premeiotic pachytene spermatocytes and
in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating
spermatocytes and mature sperm
basic FUNCTION
  • a kinase (PRKA,regulating subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function
  • playing a role in regulating the Rb pathway, and its dysregulation may contribute significantly to alterations in cell cycle regulation
  • role for this anchored kinase/microtubule effector protein network in the propagation of cell motility
  • organizes IQGAP1 and GSK3B at the leading edge of motile cells in response to growth factors
  • participates in the integration and processing of calcium and cAMP signals that underlie directional mobilization of a microtubule-associated network at the leading edge of cells
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • formation of an IQGAP2-AKAP11 core complex initiates a subsequent phase of protein recruitment that includes the small GTPase Rac
  • AKAP11 serves as a platform for the assembly of a CLASP2-IQGAP sub-complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IQGAP2 and AKAP11 act synergistically to sustain PKA-mediated recruitment of effectors such as Rac GTPases that impact the actin cytoskeleton
  • AKAP11 interacts with the cytoskeletal scaffolding protein IQGAP1 to influence cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oral cancer
    tumoral        
    alters the rate of microtubule polymerization and the lateral tracking of growing microtubules and retards cell migration in metastatic human cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS