Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARHGEF17 contributors: mct - updated : 11-03-2009
HGNC name Rho guanine nucleotide exchange factor (GEF) 17
HGNC id 21726
DNA
TYPE functioning gene
STRUCTURE 60.47 kb     21 Exon(s)
MAPPING cloned Y linked N status provisional
regionally located related to breakpoint cluster region BCR
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 7830 221.5 2063 - Bloethner (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a calponin-homology (CH) domain
  • a DBL-homology (dh) domain
  • a PH domain
  • one SH2 domain and two SH3 domains
  • one zinc-dependent phorbol-ester and DAG binding domain
  • HOMOLOGY
    intraspecies homolog to breakpoint cluster region BCR
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • coupling tyrosine kinase signals with the activation of the rho/rac gtpases, thus leading to cell differentiation and/or proliferation
  • potential novel tumor suppressor in melanoma (Bloethner 2008)
  • have a crucial role in activating small GTPases by exchanging GDP for GTP and which regulate various cellular functions including actin cytoskeleton organization, activation of kinase cascades, mitogenesis, transcriptional activation, and stimulation of DNA synthesis (Bloethner 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS