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FLASH GENE
Symbol ZFYVE26 contributors: shn - updated : 06-09-2012
HGNC name zinc finger, FYVE domain containing 26
HGNC id 20761
DNA
TYPE functioning gene
STRUCTURE 70.06 kb     42 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D14S981 - D14S125 - ZFYVE26 - D14S1069 - D14S1065 - tel
Physical map
LOC387993 14 hypothetical gene supported by BC033546 GPHN 14q23.1/14q23,3 gephyrin C14orf54 14 chromosome 14 open reading frame 54 LOC260329 14q23 splicing factor 3b, subunit 4, 49kD pseudogene MPP5 14q23.3 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) ATP6V1D 14q23-q24.2 ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D EIF2S1 14q21.3 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa PLEK2 14q23.1-q23.2 pleckstrin 2 FLJ33387 14q24.1 hypothetical protein FLJ33387 PIGH 2p21-p16 phosphatidylinositol glycan, class H LOC390490 14 similar to Ac2-008 ARG2 14q24.1-q24.3 arginase, type II VTI1B 14q23,3 vesicle transport through interaction with t-SNAREs homolog 1B (yeast) COX7A3P 14 cytochrome c oxidase subunit VIIa polypeptide 3 pseudogene RDH11 14q23-q24.3 retinol dehydrogenase 11 (all-trans and 9-cis) RPL21P9 14q23.3 ribosomal protein L21 pseudogene 9 RDH12 14q23.3 retinol dehydrogenase 12 (all-trans and 9-cis) ZFYVE26 14q23.2-q24.2 zinc finger, FYVE domain containing 26 RAD51L1 14q24.1 RAD51-like 1 (S. cerevisiae) RPL7AP5 14 ribosomal protein L7a pseudogene 5 RPL12P7 14 ribosomal protein L12 pseudogene 7 ZFP36L1 14q22-q24 zinc finger protein 36, C3H type-like 1 MAGOHP 14 mago-nashi homolog, proliferation-associated pseudogene (Drosophila) BLZF2P 14q24.1 basic leucine zipper nuclear factor 2 pseudogene ACTN1 14q24.1 actinin, alpha 1 RPS29P1 14 ribosomal protein S29 pseudogene 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
42 - 9688 284.6 2539 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly Homo sapiens
 placenta   highly Homo sapiens
Lymphoid/Immunethymus   highly Homo sapiens
Nervousbrain   predominantly Homo sapiens
 spinal cord   moderately Homo sapiens
Reproductivemale systemtestis  highly Homo sapiens
Respiratorylung   highly Homo sapiens
Visualeyeretina  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FYVE-type zinc finger domain
  • a putative zinc finger C2H2 and leucine zipper domains
    • HOMOLOGY
    interspecies ortholog to Zfyve26, Mus musculus
    ortholog to Zfyve26, Rattus norvegicus
    ortholog to ZFYVE26, Pan troglodytes
    ortholog to zfyve26, Danio rerio
    Homologene
    FAMILY
  • FYVE-finger family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    text localize to the endosomal membrane traffic compartment, suggesting that the long axons of the corticospinal tract may be especially vulnerable to endosomal dysfunction
    basic FUNCTION
  • may be playing a role in intracellular trafficking
  • involved in the abscission step during cytokinesis
  • important for proper development of the axons of spinal motor neurons
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS nervous system , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • microtubule motor KIF13A and tetratricopeptide repeat domain 19, TTC19
  • KIAA0415
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG15
    Susceptibility
  • atypical juvenile parkinsonism
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • SPG15 knock-down in zebrafish by morpholino antisense oligonucleotides lead to locomotor impairment and abnormal branching of spinal cord motor neurons at the neuromuscular junction