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FLASH GENE

Symbol

ZFYVE16

contributors: mct/npt - updated : 05-06-2019

HGNC name	zinc finger, FYVE domain containing 16
HGNC id	20756

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	75.76 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D5S682 - D5S2451 - ZFYVE16 - D5S1437 - qter
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014733 18 - 10751 NP_055548 - 1539 - 2010 19887107 NM_001105251 19 - 10944 NP_001098721 - 1539 - 2010 19887107 NM_001349434 19 - 10866 NP_001336363 - 1539 - 2010 19887107 NM_001284236 19 - 10805 NP_001271165 - 1539 - 2010 19887107 NM_001284237 4 - 2892 NP_001271166 - 809 - 2010 19887107

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea   highly Nervous brain           spinal cord         Urinary bladder       highly Visual eye retina         eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	FYVE zinc finger
	a protein-phosphatase-binding motif, which functions to negatively modulate BMP signals through receptor dephosphorylation
	C-terminal half is responsible for interaction with the C-terminal region of TOM1 and for recruitment of TOM1 and clathrin to endosomes

HOMOLOGY

interspecies

homolog to C.elegans cosmid D1022

intraspecies

homolog to SARA1

Homologene

FAMILY

FYVE-domain protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic

basic FUNCTION	playing a potential roles in regulating membrane traffic
	facilitates TGF- signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing SMAD4 to the proximity of the receptor complex
	plays an important role in both positive and negative feedback regulation of the BMP signaling pathway, acting a SMAD anchor for receptor activation in BMP signaling
	plays an important role in both positive and negative feedback regulation of the BMP signaling pathway (Shi 2007)
	endosome-associated FYVE-domain protein endofin which acts as a Smad anchor for receptor activation in BMP signaling (Shi 2007)
	possible role of Endofin in the modulation of MAPK pathway
	is involved in endosomal trafficking and in TGFB1, BMP, and EGFR signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	targeted to early endosomes by its FYVE domain and colocalized with SARA1
	interacting with TOM1
	modulates hepcidin through BMP-SMAD signalling
	ZFYVE16 binds to SMAD4 and their binding affects the formation of SMAD2/3-SMAD4 complex in TGFB1 signaling
	ZFYVE9, ZFYVE16 recruit the tumor supressor PTPN23, a master regulator of endosomal sorting and ESCRT-dependent receptor downregulation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS