basic FUNCTION
| involved in the program of cellular senescence in the renal cell carcinoma cell line RCC23 |
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telomerase repressor mediating permanent growth arrest of the tumor cells |
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RNA component acts as a template for the addition of telomeric repeat sequences |
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involved in telomere maintenance (critical enzyme for the long term proliferation of immortal tumor cells) |
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assembles not one but two sets of all four of the H/ACA RNP core proteins, DKC1, NOP10, NHP2, and GAR1 (Egan 2010) |
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essential role of TERT, and TERC in the hematopoietic system sugesting that telomerase levels in hematopoietic cells, while limiting and unable to prevent overall telomere shortening, are nevertheless crucial to maintain telomere homeostasis with age |
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TERT and TERC exert both reverse transcriptase-related (canonical) and noncanonical functions to affect tumor genome evolution through suppression or induction of polyploidization |
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new role for PARN in the biogenesis of TERC, providing a mechanism linking PARN mutations to telomere diseases |