Selected-GenAtlas references SOURCE GeneCards NCBI Gene Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TERC contributors: mct/npt - updated : 06-09-2016
HGNC name telomerase RNA component
HGNC id 11727
DNA
TYPE small rna
STRUCTURE 0.45 kb     1 Exon(s)
regulatory sequence Promoter
text structure
  • existence of multiple quadruplex structures within the 5prime region of TERC
  • MAPPING cloned Y linked   status provisional
    Map pter - D3S1129 - [D3S685 - D3S1100 - D3S926 - D3S643 - D3S1009 ] - D3S714 - cen
    Authors Tanaka (98)
    Text [TERC ]
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text
  • strongly, in tissues (undifferentiated neuroepithelium, epithelium, mesenchyme)
  • dividing cells (testis, lymphoid follicles, regenerative epithelia)
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • H/ACA motif that directs specific pathways of endogenous telomerase holoenzyme assembly, function, and regulation (Egan 2010)
  • pseudoknot region
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Terc
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in the program of cellular senescence in the renal cell carcinoma cell line RCC23
  • telomerase repressor mediating permanent growth arrest of the tumor cells
  • RNA component acts as a template for the addition of telomeric repeat sequences
  • involved in telomere maintenance (critical enzyme for the long term proliferation of immortal tumor cells)
  • assembles not one but two sets of all four of the H/ACA RNP core proteins, DKC1, NOP10, NHP2, and GAR1 (Egan 2010)
  • essential role of TERT, and TERC in the hematopoietic system sugesting that telomerase levels in hematopoietic cells, while limiting and unable to prevent overall telomere shortening, are nevertheless crucial to maintain telomere homeostasis with age
  • TERT and TERC exert both reverse transcriptase-related (canonical) and noncanonical functions to affect tumor genome evolution through suppression or induction of polyploidization
  • new role for PARN in the biogenesis of TERC, providing a mechanism linking PARN mutations to telomere diseases
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RNA component of the telomerase complex associating with NOLA1, NOLA2, NOLA3, DKC1
  • INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • TERT
  • interacts with the N-terminal accessory domain of DHX36 known to bind specifically to the parallel-strand G-quadruplex substrates resolved by the helicase domain
  • TERC is a true target of DHX36
  • PARN increased TERC levels by deadenylating TERC, thereby limiting its degradation by EXOSC10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DKC2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    facilitating the malignant transformation of benign tumors and enhancing the chromosomal instability of cancers
    constitutional     --low  
    in DKC cells which have shorter telomeres
    tumoral   amplification    
    in cervical cancer, high grade with poor prognosis (Tu 2009)
    Susceptibility to variation of telomere length
    Variant & Polymorphism other
  • variants in TERC can impede telomere elongation causing stem cells to enter premature replicative senescence and/or apoptosis as telomeres become critically short
  • Candidate gene
    Marker
  • detection of genomic amplification of TERC is a noninvasive and effective approach for high-grade cervical lesions and invasive cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • Terc -/- mouse
  • displaying severe growth defect