basic FUNCTION
| proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, proton-sensing and psychosine-sensitive G-protein-coupled receptor |
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expression of GPR65 by immune cells may regulate responses in acidic microenvironments |
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proton-sensing GPCRs which could have some roles in nociception or in compensation of loss of ACCN3 gene |
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functions as an extracellular pH sensor which enhances cAMP production in response to an acidified extracellular environment |
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involved in the establishment of immunological autotolerance |
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orphan G protein-coupled receptor (GPCR) in apoptotic thymocytes |
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may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis |
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extracellular pH-sensing G protein-coupled receptor that is overexpressed in various tumors and tumor cell lines |
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enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation |
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candidate molecule that contributes to acid resistance and tumor proliferation |
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is likely to trigger adaptations that allow the tumor cells to survive in an acidic environment and promote further tumor development |
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acts likely as a negative regulator of inflammation |
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proton sensor, inhibits the production of pro-inflammatory cytokines induced by extracellular acidification |
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GPR65 is vital regulatory genes upstream of MMP3 |
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potential involvement of GPR65 in behavioral response relevant to depression |
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GPR4, GPR65 and GPR68 are G protein-coupled receptors that aid cells to sense and survive conditions of acidic pH |
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GPR65 may be involved in a mechanism that supports survival of photoreceptors in the degenerating retina |
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is a negative regulator for lung neutrophilic inflammation and injury, in part, through the inhibition of chemokine production |
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GPR4, GPR68, GPR65, GPR132 are regulators of cell proliferation and migration during tumor growth and wound healing |