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FLASH GENE
Symbol PTPRK contributors: - updated : 16-06-2007
HGNC name protein tyrosine phosphatase, receptor type, K
HGNC id 9674
DNA
TYPE functioning gene
STRUCTURE 551.00 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 liver   lowly
 pharynx   highly
Endocrinepancreas   lowly
Lymphoid/Immunespleen    
Nervousbrain   highly
Reproductivefemale systemovary   
 male systemprostate   
Respiratorylung   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines epidermal cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a MAM domain
  • an immunoglobulin-like C2-type domain
  • four fibronectin type III-like domain
  • two protein tyrosine phosphatase domains
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Ptprk
    homolog to C.elegans f56d1.4
    Homologene
    FAMILY
    CATEGORY enzyme , receptor membrane phosphatase
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    text type I membrane protein
    basic FUNCTION
  • involved in regulation of processes involving cell contact and adhesion such as growth control, tumor invasion
  • and metastasis
  • playing a role with PTPN6 in the regulation, maintenance, and restitution of cell adhesions in a complex epithelial organ such as the pancreas
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forms complexes with beta-catenin and gamma-catenin/plakoglobin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • beta-catenin
  • gamma-catenin/plakoglobin
  • dephosphorylates EGFR and thereby regulates its function in keratinocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS