basic FUNCTION
| actin dependent regulator of chromatin structure, acting as a tumor suppressor |
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involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration |
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of DNA-nucleosome topology) |
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playing an essential role for normal cell cycle arrest |
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necessary facilitator of BRG1-mediated chromatin remodeling required for SWI/SNF-dependent transcriptional activation |
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key component of the gene regulatory machinery in ES cells controlling self-renewal, differentiation, and cell lineage decisions |
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implicated in the cross talk of histone modifications |
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plays an important role in early development |
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coactivator for the glucocorticoid receptor and an essential gene for FAS-mediated apoptosis |
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Trithorax g protein functioning as an E3 ubiquitin ligase adapter for histone H2BK120 and having important implications for chromatin remodeling by SWI/SNF and H2B monoubiquitination, an upstream event of H3K4 trimethylation associated with gene activation |
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functioning as a tumor-suppressor gene |
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can bind to AT-rich DNA sequences and is a component of the adenosine triphosphate-dependent chromatin modeling complex switch/sucrose-nonfermentable (SWI/SNF) |
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may be a candidate tumor-suppressor genes (TSGs) in breast cancer |
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tumor suppressor that collaborates with TP53 to regulate CDKN1A and SMAD3 transcription and tumor growth in gynecologic cancers |
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regulates cardiac progenitor cell (CPC) differentiation by modeling the chromatin accessibility at a subset of key genes essential for cardiogenesis |
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is a nucleocytoplasmic protein whose stability depends on its subcellular localization |
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tumor suppressor gene involved in chromatin remodelling |
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specific requirement of the PI3K/AKT pathway in ARID1A-deficient tumors, revealing a synthetic lethal interaction between loss of ARID1A expression and inhibition of the PI3K/AKT pathway |