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FLASH GENE
Symbol ENTPD3 contributors: mct - updated : 22/11/2008
HGNC name ectonucleoside triphosphate diphosphohydrolase 3
HGNC id 3365
DNA
TYPE like-sequence
STRUCTURE 41.42 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CMYA1 3p21.33 cardiomyopathy associated 1 CX3CR1 3p21.32-p21.31 chemokine (C-X3-C motif) receptor 1 CCR8 3p21.32-p21.31 chemokine (C-C motif) receptor 8 hnRNPA1p 3p21.33 heterogeneous nuclear ribonucleoprotein A1 pseudogene LOC389109 3 similar to elongation factor 1 alpha LOC389110 3 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC389111 3 similar to RIKEN cDNA 1110038F21 FLJ20551 3p21.33 hypothetical protein FLJ20551 LAMR1 3p21.3 laminin receptor 1 (ribosomal protein SA, 67kDa) MOBP 3p22-p21.33 myelin-associated oligodendrocyte basic protein MYRIP 3p21.3 myosin VIIA and Rab interacting protein GC20 3p21.33 translation factor sui1 homolog ENTPD3 3p21.3 ectonucleoside triphosphate diphosphohydrolase 3 RPL14 3p23-p21.2 ribosomal protein L14 FLJ90764 3p21.33 hypothetical protein FLJ90764 MGC50836 3p21.33 hypothetical protein MGC50836 FLJ45246 3p21.33 FLJ45246 protein LOC344682 3p21.33 similar to Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) LOC389112 3 similar to ribosomal protein S27 MRPS31P1 3p21.33 mitochondrial ribosomal protein S31 pseudogene 1 CTNNB1 3p22-p21.3 catenin (cadherin-associated protein), beta 1, 88kDa DKFZp434E1822 3p21.33 hypothetical protein DKFZp434E1822
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2807 - 529 - Ivanenkov (2005), Crawford (2007)
only this isoform is enzymatically active and properly trafficked to the plasma membrane
- - - - - - Crawford (2007)
  • use of an alternative terminal exon (exon 11) in place of the terminal exon (exon 12) in the full-length NTPDase3
  • protein lacking the C-terminal cytoplasmic sequence, the C-terminal transmembrane helix, and apyrase conserved region 5
  • may be playing a role in the regulation of ENTPD3 nucleotidase activity
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     pancreas   highly
    Nervousnerve   highly
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two potential transmembrane segments at the N and C termini
  • four apyrase-conserved regions which is characteristic of NTPases in the N terminal region
  • N-linked glycosylation sites processed to complex oligosaccharides
  • secondary structure five disulfide bonds
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to lymphoid cell activation antigen CD39
    Homologene
    FAMILY
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface, membrane-bound enzyme hydrolyzing extracellular nucleotides, thereby modulating purinergic signaling
  • invovedd in the control of purinergic signaling, in those cells and tissues expressing both NTPDase3alpha and NTPDase3beta
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    extracellular nucleotides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS