Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ENTPD6 contributors: - updated : 16-09-2006
HGNC name ectonucleoside triphosphate diphosphohydrolase 6 (putative function)
HGNC id 3368
DNA
TYPE functioning gene
STRUCTURE 31.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - THBD - D20S184 - D20S871 - ENTPD6 - D20S863 - cen
Authors Chadwick (98),LDB (99)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestiveintestinelarge intestinecolon highly
Endocrineneuroendocrinepituitary  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one transmembrane segment at the N terminus
  • four apyrase conserved regions (ACR) in the N terminal region
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to 1 lymphoid cell activation antigen CD39
    Homologene
    FAMILY GDA1/CD39 ntpase family
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text one recruted form
    basic FUNCTION
  • might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides
  • cation-dependent enzyme that hydrolyzing ATP and ADP and also other di- and triphosphate nucleosides, acting at an optimum pH of 8.0
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    extracellular nucleotides
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • calcium Ca2+
  • magnesium Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS