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FLASH GENE
Symbol NPAS1 contributors: mct - updated : 07-10-2006
HGNC name neuronal PAS domain protein 1
HGNC id 7894
DNA
TYPE functioning gene
STRUCTURE 24.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 salivary gland   highly
Lymphoid/Immunetonsils   highly
Nervousbrain   predominantly
Skin/Tegumentskin   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain, at the late embryonic stage
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) juxtaposed to a stretch of approximately 300AA, termed the PAS (Per - ARNT - Sim) domain
  • two PAS (PER-ARNT-SIM) dimerization domains
  • a PAS-associated C-terminal (PAC) domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Npas1
    homolog to Drosophila trh
    homolog to C.elegans C41G7.5
    Homologene
    FAMILY basic helix-loop-helix (bHLH)-PAS family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing protective or modulatory roles during late embryogenesis and postnatal development
  • playing a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text late embryogenesis and postnatal development
    PATHWAY
    metabolism
    signaling
    a component required dimerization with another BHLH protein for efficient DNA binding
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein binds to the enhancer region of EPO
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS