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FLASH GENE
Symbol TAF9 contributors: mct - updated : 19-05-2020
HGNC name TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
HGNC id 11542
DNA
TYPE functioning gene
STRUCTURE 5.27 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text TSPYL2 and TAF9 mRNAs are translated from different ATG codons and use distinct reading frames, resulting in them having no identity in their respective protein sequences
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 splicing 1163 - 264 - 2015 26282181
  • TAF9-V1 Ia
  • 5 splicing 962 - 172 - 2015 26282181
    5 - 1199 - 169 - 2015 26282181
    3 - 1482 - 264 - 2015 26282181
  • V4 Ia
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemuterus  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a P-loop nucleotide binding motif and ATPase activity
  • a TAF9 conserved C-terminal region (CRD), having a crucial role in genome-wide transcription, and required for FAM48A and TBP promoter occupancy to promote transcriptional activation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text specifically nuclear and distributed in a widespread, diffuse nucleoplasmic pattern, excluding nucleoli, with some concentration also in Cajal bodies
    basic FUNCTION
  • functionally supports KLF1 activity by enhancing its ability to activate the beta-globin gene (Sengupta 2009)
  • TBPL1 and TAF9 regulate fatty acid composition of several classes of phospholipids
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mammalian STAGA (SUPT3H-TAF9-TADA1-KAT2A-SUPT7L acetyltransferase) a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors (Martinez 2001)
  • TBR1–CASK–TAF9 complex regulates expression of the NMDA receptor subunit 2b (GRIN2B) (Huang 2009)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • interacting with the herpes simplex acidic virus transactivator protein 16 (VP16) as well as with the general transcription factor TFIIB
  • interacting with COIL (carboxyl-terminal residues of coilin appear essential for the interaction)
  • interacts with a conserved beta-globin downstream promoter element, and ablation of this interaction by beta-thalassemia-causing mutations decreases its promoter activity and disables superactivation (Sengupta 2009)
  • interaction between Gli proteins and a transcription coactivator TBP-associated factor 9 (TAF9) with role in regulating Gli transactivation
  • TAF9 interacts with the oncogenic GLI family members GLI1 and GLI2 but not GLI3
  • TP53 sequesters TAF9 from GLI1, which may contribute to inhibition of GLI1 activity by TP53 and potentially impact therapeutic success of agents targeting GLI-TAF9 interactions in cancer
  • MAGEC2 directly interacted with TAF9, which may provide novel information for identifying the oncogenic functions of HCA587/MAGEE1 in tumor cells
  • key checkpoint function for the chaperonin TCP1, which specifically associates with nascent TAF5 for subsequent handover to TAF6-TAF9 and ultimate holo-TBP formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS