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FLASH GENE
Symbol PLS1 contributors: mct - updated : 01-04-2016
HGNC name plastin 1 (I isoform)
HGNC id 9090
DNA
TYPE functioning gene
STRUCTURE 117.28 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2 TRIM42 3q23-24 tripartite motif-containing 42 LOC391583 3 similar to 60S ribosomal protein L23a FLJ10618 3q23 hypothetical protein FLJ10618 SSB4 3q23 SPRY domain-containing SOCS box protein SSB-4 FLJ23751 3q23 hypothetical protein FLJ23751 FLJ35036 3q23 hypothetical protein FLJ35036 LOC391584 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RASA2 3q22-q23 RAS p21 protein activator 2 LOC389153 3 LOC389153 LOC391585 3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) RNF7 3q22-q24 ring finger protein 7 GPRK7 3q21-q24 G protein-coupled receptor kinase 7 ATP1B3 3q22-q23 ATPase, Na+/K+ transporting, beta 3 polypeptide TFDP2 3q23 transcription factor Dp-2 (E2F dimerization partner 2) MGC40579 3q23 hypothetical protein MGC40579 SEP1 3q23 strand-exchange protein 1 ATR 3q22-q24 ataxia telangiectasia and Rad3 related PLS1 3q23 plastin 1 (I isoform) TRPC1 3q22-q24 transient receptor potential cation channel, subfamily C, member 1 PCOLCE2 3q21-q24 procollagen C-endopeptidase enhancer 2 PAQR9 3q23 progestin and adipoQ receptor family member IX SR140 3q23-q24 progestin and adipoQ receptor family member IX LOC389154 3 LOC389154 CHST2 3q24 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 PBXP1 3q22-q23 pre-B-cell leukemia transcription factor pseudogene 1 SLC9A9 3p14 solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 LOC257039 3q24 similar to ribosomal protein S17 MGC33365 3q24 hypothetical protein MGC33365 GM2AP 3q21-q25 GM2 ganglioside activator protein pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3720 - 629 - 1994 8139549
16 - 3735 - 629 - 1994 8139549
15 - 3880 - 629 - 1994 8139549
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon  
 liver    
 stomach   lowly
Respiratorylung   lowly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two actin-binding domains,
  • four calponin-homology (CH) domains
  • two EF-hand calcium-binding domains
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Pls1
    homolog to Drosophila Fim
    homolog to C.elegans Y104H12BR.1
    Homologene
    FAMILY family of actin-binding proteins
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text brush border of small intestine
    basic FUNCTION
  • acting as an actin-bundling protein in the absence of calcium
  • along with villin and espin is a prominent actin-bundling protein of the intestinal brush border microvilli
  • emerges as an important regulator of brush border morphology and stability through a novel role in the organization of the terminal web, possibly by connecting actin filaments to the underlying intermediate filament network
  • in contrast to other actin-bundling proteins such as ESPN, USH1C or EPS8, PLS1 is dispensable for the initial formation of stereocilia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • binding to actin
  • interacts with KRT19, possibly contributing to anchoring the rootlets to the keratin network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • plastin 1-deficient mice have conspicuous ultrastructural alterations: microvilli are shorter and constricted at their base, and, strikingly, their core actin bundles lack true rootlets