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FLASH GENE
Symbol LY75 contributors: mct - updated : 14-11-2017
HGNC name lymphocyte antigen 75
HGNC id 6729
DNA
TYPE functioning gene
STRUCTURE 101.40 kb     35 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
33 - 8919 - 1873 - 1998 10233701
35 - 6936 205 1722 - 1998 9553150
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 thymus   highly
Respiratoryrespiratory tracttrachea  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/Immunedendritic cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NH(2) terminal cysteine-rich and fibronectin type II domains
  • a signal peptide
  • 10 C-type lectin domains
  • ricin b-type lectin domain
  • a transmembrane domain and a cytoplasmic tail
  • an internalization sequence in its cytoplasmic tail
  • HOMOLOGY
    intraspecies homolog to macrophage mannose receptor (MMR)
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • putative antigen-uptake receptor on dendritic cells
  • acting as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment
  • plays an important role in thymocyte development
  • acts as a recognition receptor for dying cells, potentially providing an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance
  • endocytic receptor that is expressed at high levels by cortical thymic epithelial cells and by dendritic cell (DC) subsets, including the splenic CD8+ DC population that is responsible for cross-presentation of apoptotic cell-derived antigens
  • mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells
  • has endocytic capacity, recycles through late endosomal/lysosomal compartments, and facilitates antigen presentation when targeted with antigen-bearing monoclonal antibodies
  • critical role for CD205(+) cDCs in the regulation of T-cell immunity and homeostasis
  • facilitates dendritic cells (DC) maturation induced by CpG oligonucleotides (ODN)
  • does not play an overt role in T cell development or selection
  • is one of the major endocytotic receptors on dendritic cells and has been widely used for vaccine generation against viruses and tumors
  • is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism
  • modulates cellular phenotype and metastatic potential of ovarian cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly bound CpG ODN and facilitated uptake by CD8+ DC, the key producers of IL12
  • cell & other
  • LY75 only binds to apoptotic and necrotic cells at acidic pH, whereas live cells cannot be recognized by LY75 at either acidic or basic conditions
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion protein between LY75 and a novel C-type lectin CD302 in Hodgkin's lymphoma
    tumoral     --over  
    in advanced epithelial ovarian cancer (EOC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • sensitive and specific marker for thymoma but not thymic carcinoma
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    LY75 targeting should be explored as a vaccination approach against EBV-associated malignancies
    immunologyinfectious 
    LY75 targeting should be explored as a vaccination approach against symptomatic primary EBV infection
    ANIMAL & CELL MODELS