basic FUNCTION
| putative antigen-uptake receptor on dendritic cells |
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acting as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment |
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plays an important role in thymocyte development |
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acts as a recognition receptor for dying cells, potentially providing an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance |
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endocytic receptor that is expressed at high levels by cortical thymic epithelial cells and by dendritic cell (DC) subsets, including the splenic CD8+ DC population that is responsible for cross-presentation of apoptotic cell-derived antigens |
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mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells |
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has endocytic capacity, recycles through late endosomal/lysosomal compartments, and facilitates antigen presentation when targeted with antigen-bearing monoclonal antibodies |
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critical role for CD205(+) cDCs in the regulation of T-cell immunity and homeostasis |
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facilitates dendritic cells (DC) maturation induced by CpG oligonucleotides (ODN) |
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does not play an overt role in T cell development or selection |
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is one of the major endocytotic receptors on dendritic cells and has been widely used for vaccine generation against viruses and tumors |
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is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism |
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modulates cellular phenotype and metastatic potential of ovarian cancer cells |